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In univariate analyses, gEUD, V5, V10, V20, V30, and mean lung dose (MLD) were positively associated with G2+ pneumonitis risk, whereas current smoking status was associated with lower odds of pneumonitis. Adjusting for incomplete follow-up, estimated rates for G2+ and G3+ were 14% and 2%, respectively. Seven percent of cases (n = 94) were G2+ and <1% (n = 11) were G3+. The overall rate of pneumonitis of any grade in the 6 months following RT was 16% (208 cases). Logistic regression models were fit to quantify univariable associations with dose and clinical factors, and stepwise Akaike information criterion-based modeling was used to build multivariable prediction models. Pneumonitis was modeled as either grade ≥2 (G2+) or grade ≥3 (G3+). Pneumonitis occurring within 6 months of treatment was graded by local practitioners and collected prospectively from 27 academic and community clinics participating in a state-wide quality consortium. We analyzed toxicity data from a state-wide consortium to develop an integrated pneumonitis risk model.Īll patients (N = 1302) received conventionally fractionated RT for stage II-III non-small cell lung cancer between April 2012 and July 2019. Multiple factors influence the risk of developing pneumonitis after radiation therapy (RT) for lung cancer, but few resources exist to guide clinicians in predicting risk in an individual patient treated with modern techniques. Electronic address: 11 Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan Department of Biostatistics, University of Michigan, Ann Arbor, Michigan. 10 Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.8 Department of Radiation Oncology, Wayne State University, Detroit, Michigan.

4 Department of Radiation Oncology, Lacks Cancer Center, University of Michigan, Grand Rapids, Michigan.3 College of Osteopathic Medicine, Kansas City University of Medicine and Biosciences, Kansas City, Missouri.2 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.1 Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.